Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential

Editorial: Molecular Regulation and Therapeutic Potential of Thermogenic Fat Cells

Much of systemic metabolism depends on the activity and function of adipose tissue. Adipocytes in mammals fall into two categories classified by their primary functions: white fat cells that mediate energy storage and thermogenic fat cells that counteract hypothermia and obesity through adap-tive thermogenesis. Whereas white fat and its function as an energy reservoir and endocrine organ have b...

Epicardial Fat: Physiological, Pathological, and Therapeutic Implications

Epicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue's behavior is considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased...

Carnosine: physiological properties and therapeutic potential.

Carnosine and related dipeptides are naturally-occurring histidine-containing compounds. They are found in several tissues, particularly in skeletal muscle. Since carnosine was discovered in Russia in 1900, there have been many theories about its biological functions, but none has been proved beyond reasonable doubt [1, 2]. However, this compound is reported to possess antioxidant, buffering, i...

Thermogenic mechanisms in brown fat.

Recent insights into development, metabolic function and therapeutic potential